Foldit: Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

January 22, 2012

Computational enzyme design holds promise for the production of renewable fuels, drugs and chemicals. De novo enzyme design has generated catalysts for several reactions, but with lower catalytic efficiencies than naturally occurring enzymes. Here we […]

Squaring and Scripting the ESP Game

January 5, 2012

The ESP Game tends to generate “low effort” or “surface semantics” tags. This paper presents two variations of the ESP Games called “squaring” and “scripting” that trim the ESP Game to collect “deep semantics” tags. […]